Owen Sitole College of Agriculture (OSCA), formerly known as Cwaka Agricultural College, was established in 1968. The former name of the college, Cwaka, was derived from the Cwaka stream, which means a calm stream.
On 20 April 1985, the college was renamed after the late Inkosi Sigidisabathembu Owen Lancelot Sitole, the first Councillor for Agriculture and subsequently Minister of Agriculture for KwaZulu.
In January 1990, the management of the college was taken over by the Technikon Mangosuthu and it was run as a satellite campus for the training of students in agriculture, nature conservation and home economics. In June 1991, the Technikon decided to rationalize and they withdrew and transferred all training to the main campus in Umlazi near Durban.
Since that date the college was not open for students, but was used for in-service training of staff. In January 1996 the college reopened for the training of students.